Comprehensive dietary and internal exposure assessment of deoxynivalenol contamination in a high-risk area in China using duplicate diet studies and urinary biomarkers

This study assessed the exposure of 199 Chinese population samples from Anhui Province, China, to deoxynivalenol (DON) based on their dietary intake and urinary biomarkers. is first compare between both procedures DON detection (diet human bio-monitoring approach) within same population. Food urine were collected healthy participants. The highest concentrations its derivatives detected in wheat-based products. Both metabolite, DOM-1, found samples. Total (free + conjugated) was 99% samples, with a mean concentration at 109.21 ng mL?1. estimated (EDI) level calculated food consumption contamination data obtained as 2.54 ± 1.63 ?g kg?1 bw d?1, while probable daily (PDI) biomarkers be 3.96 4.20 d?1. A significant correlation evidenced EDI PDI, exceeding provisional maximum tolerable intake. Elevated contaminant levels observed adolescent group compared children, adults, elders, thereby indicating potential health risk them. excretion rate adolescents approximately 2.5 times that adult participants, possibly indicative higher metabolic activity, which needs further in-depth investigation.